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To investigate the reproducibility of shear wave elastography (SWE) among operators, machines and probes in a phantom. Moreover, to evaluate the effect of depth and the accuracy of the embedded inclusions.
In-vitro stiffness measurements of six inclusions (10kPa, 40kPa and 60kPa) embedded at two depths (1.5cm and 5cm) in an elastography phantom. The measurements obtained by two sonographers using two ultrasound machines; the SuperSonic Imagine Aixplorer using the XC6-1, SL10-2 and SL18-5 probes, and the General Electric LOGIQ E9 using the 9L-D probe. The variability was evaluated using the coefficient of variation. The reproducibility was calculated using an intraclass correlation coefficient (ICC).
For shallow inclusions, low variability was observed between the results obtained by each operator (range 0.9%–5.4%). However, the variability increased significantly in the deeper inclusions (range 2.4–80.8%). The measurement difference between the operators was 1%–15% in superficial inclusions and 3%–43% in deep inclusions. The inter-operator reproducibility was almost perfect (ICC>0.90). The measurement difference between the machines was 0–15% in superficial inclusions and 38.6%–82.9% in deep inclusions. In superficial inclusions, there was an excellent reproducibility between the three probes (ICC>0.97). On average, the means of the 10 kPa inclusions’ stiffness were overestimated by 16%, while those at 40 kPa and 60 kPa were underestimated by 42% and 48%, respectively.
Phantom SWE measurements were reproducible between operators, machines and probes at superficial depths only. SWE measurements acquired in deep regions should not be used interchangeably between operators, machines or probes.
To investigate muscle stiffness and strength in rheumatoid arthritis patients compared to healthy controls.
A sample of 80 RA patients from three discrete groups: 1 – newly diagnosed treatment-naïve RA (n = 29), 2 – active RA for at least 1 year (n = 18) and 3 – in remission RA for at least 1 year (n = 33), was compared to 40 healthy controls. Shear wave velocity (SWV) was measured using shear wave elastography as a surrogate for tissue stiffness in multiple muscles. All participants performed isometric grip strength, timed get-up-and-go test, 30-s chair stand test and isokinetic knee extension/flexion (60°/s). The difference in SWV amongst the groups was tested using one-way ANOVA, and the correlation between SWV and muscle strength results were calculated using Pearson’s coefficients.
The mean age ± SD was 61.2 ± 12.8 for RA patients and 61.5 ± 10.5 years for controls. SWV was not significantly different amongst the groups on all muscles (p > .05). In comparison to controls, the new and active RA groups showed a significantly lower isokinetic strength by –29% (p = .013) and –28% (p = .040), fewer chair stands by –28% (p = .001) and –44% (p ...
To investigate muscle stiffness changes in patients treated for giant cell arteritis (GCA) with high‐dose oral glucocorticoids.Methods
Using ultrasound elastography, shear wave velocity (SWV) was measured in the quadriceps, hamstrings and biceps brachii muscles of 14 patients with GCA (4 male, mean age ± SD, 68.2 ± 4.3 years) within the first 2 weeks of initiating glucocorticoid treatment (baseline) and repeated after 3 and 6 months treatment. Muscle strength and performance tests were performed at each visit. Baseline measures were compared with those from 14 healthy controls. Linear mixed models were used to test for change in patient measures over time.Results
At baseline, muscle SWV in patients was not significantly different from controls. With glucocorticoid treatment, there was a reduction in SWV in the leg but not the arm muscles. SWV decreased by a mean of 14% (range 8.3%‐17.3%; P = .001) after 3 months and 18% (range 10.2%‐25.3%; P ...
Patients in hospital intensive care units have long been recognized as being at high risk for developing infections from bacteria, fungi, and viruses from within the hospital locality. Risk factors for development of nosocomial infections have usually focussed on the patient’s physical condition and the number and type of invasive medical procedures administered. Using the staphylococci as its focus, this chapter presents recent evidence that some of the medications routinely used in the treatment of acutely ill patients may also be a risk factor for the development of nosocomial infections....
Introduction: Oxidative stress is integrated with declined female fertility. Our modern sedentary life style and exposure to toxins make vulnerable to body to increased amount of oxidative stress and lead to higher oxidative damage to DNA and may affect ova, sperm or the development of the embryo, leading to infertility, miscarriage and congenital defects. In the present study our aim was to assess the concentration of total oxidative stress, total antioxidant capacity, selenium and vitamin E level in women suffering from recurrent spontaneous miscarriage and intra uterine foetal death and compare levels with normal pregnant women....
Breast cancer is the leading cause of death among women around the world. Studies confirm that early-stage cancer detection can lead to better healing. This research project aims to offer a system for early detection of women breast cancer based on the technique of DC electric bio-impedance
Mammography remains the essential technique for breast exploration, the most successful in terms of monitoring and early detection of breast cancer. Unfortunately, it is an invasive, expensive method and women do not go directly for screening. Thus, we propose in this research project to design a smart mammograph for early diagnosis of breast cancer using electrical bio-impedance
Electrical bio-impedance has a high diagnostic potential for various diseases. Indeed, an impedance value different from the normal can inform us about a physiological abnormality of the individual
Indeed, this research project offers a non-invasive system that allows to simultaneously measuring the impedances of the two breasts of a patient, to compare the result and if there is a significant difference, it means that there is a problem in one of the breasts. Once the system finalized, we will carry out an impedance measurement campaign of healthy women and women with cancer to establish a meaningful database and offer a real-time automatic screening system
This research project is only the first phase. The second phase will focus on increasing the number of electrodes to precisely locate the tumor, create an image and transmit it to a smartphone...