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Early detection of breast cancer using DC bio-impedance technique سفيان محمد الحبيب منصوري

Breast cancer is the leading cause of death among women around the world. Studies confirm that early-stage cancer detection can lead to better healing. This research project aims to offer a system for early detection of women breast cancer based on the technique of DC electric bio-impedance

Mammography remains the essential technique for breast exploration, the most successful in terms of monitoring and early detection of breast cancer. Unfortunately, it is an invasive, expensive method and women do not go directly for screening. Thus, we propose in this research project to design a smart mammograph for early diagnosis of breast cancer using electrical bio-impedance

Electrical bio-impedance has a high diagnostic potential for various diseases. Indeed, an impedance value different from the normal can inform us about a physiological abnormality of the individual

Indeed, this research project offers a non-invasive system that allows to simultaneously measuring the impedances of the two breasts of a patient, to compare the result and if there is a significant difference, it means that there is a problem in one of the breasts. Once the system finalized, we will carry out an impedance measurement campaign of healthy women and women with cancer to establish a meaningful database and offer a real-time automatic screening system

This research project is only the first phase. The second phase will focus on increasing the number of electrodes to precisely locate the tumor, create an image and transmit it to a smartphone

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Muscle shear wave elastography in idiopathic inflammatory myopathies: a case–control study with MRI correlation عبدالرحمن محمد الفريح
Objective To investigate muscle stiffness in patients with idiopathic inflammatory myopathies (IIM) using shear wave elastography (SWE) and to correlate the results with muscle strength and MRI features of myositis. Materials and methods Muscle shear wave velocity (SWV) was measured in 23 active IIM patients (13 females, mean age 50.4 ± 16.1 years) and 23 matched healthy controls (13 females, mean age 50.7 ± 16.2 years). The investigated muscles included the vastus lateralis (VL), rectus femoris (RF), vastus medialis (VM) vastus intermedius (VI), biceps femoris (BF), semitendinosus (ST), semimembranosus (SM) and the biceps brachii (BB) scanned during relaxed resting and passive stretching positions. Participants performed multiple tests to evaluate their muscle strength. IIM patients had a thigh MRI to assess degrees of oedema, fatty infiltration and atrophy. Results In the resting position, IIM patients had a 12.9–22.2% significantly lower SWV (p < 0 xss=removed xss=removed xss=removed xss=removed xss=removed xss=removed xss=removed xss=removed xss=removed> Conclusion Shear wave elastography may detect abnormal reduced thigh stiffness in IIM patients. SWE measurements were significantly associated with muscle weakness and MRI signs of oedema and atrophy. Future research should investigate this new technology for monitoring disease activity. ...
The effect of ageing on shear wave elastography muscle stiffness in adults عبدالرحمن محمد الفريح
Background Skeletal muscle undergoes structural changes with ageing which may alter its biomechanical properties. Shear wave elastography (SWE) may detect these changes by measuring muscle stiffness. Aims To investigate muscle stiffness in healthy young, middle-aged and elderly cohorts using SWE and correlate it with muscle strength and mass. Methods Shear wave velocity (SWV) was measured in the quadriceps, hamstrings and biceps brachii of 26 young (range 20–35 years), 21 middle-aged (40–55) and 30 elderly (77–94) volunteers. The participants performed several muscle tests to evaluate their strength. The One-way ANOVA was used to test the muscle stiffness differences between the groups and the Pearson’s correlation coefficient to evaluate the relationship between SWV and muscle strength. Results The overall resting muscle SWV gradually decreased with age but was only significantly reduced in the elderly group (p < 0 xss=removed xss=removed xss=removed xss=removed xss=removed> Conclusions Ageing was associated with a decline in skeletal muscle stiffness which positively correlates with muscle weakness. Further research is needed to evaluate the promising role of SWE as a biomarker for sarcopenia assessment and potential falls risk prediction in elderly individuals. ...
Shear-Wave Elastography of Benign versus Malignant Musculoskeletal Soft-Tissue Masses: Comparison with Conventional US and MRI عبدالرحمن محمد الفريح
Purpose To examine if shear-wave elastography (SWE) improves the accuracy of diagnosing soft-tissue masses as benign or malignant compared with US alone or in combination with MRI. Materials and Methods Two hundred six consecutive adult participants (mean age, 57.7 years; range, 18–91 years), including 89 men (median age, 56.0 years; range, 21–91 years) and 117 women (median age, 59.1 years; range, 18–88 years), who were referred for biopsy of a soft-tissue mass were prospectively recruited from December 2015 through March 2017. Participants underwent B-mode US, MRI, and SWE prior to biopsy. Three musculoskeletal radiologists independently reviewed US images alone, followed by US and MRI images together, and classified lesions as benign, probably benign, probably malignant, or malignant. For SWE, the area under the receiver operating characteristic (ROC) curve (AUC) was calculated for transverse shear-wave velocity (SWV). Multivariable logistic regression was used to investigate the association between SWE and malignancy alongside individual demographic and imaging variables. Results At histologic examination, 79 of 206 (38%) participants had malignant lesions. SWV showed good diagnostic accuracy for lesions classified as benign or probably benign by US alone (AUC = 0.87 [95% confidence interval {CI}: 0.79, 0.95]). SWV did not provide substantive diagnostic information for lesions classified as probably malignant or malignant, whether the classification was made with or without MRI. However, multivariable modeling indicated that diagnostic accuracy may vary by lesion position (interaction P = .02; superficial, odds ratio [OR] = 17.7 [95% CI: 1.50, 207], P = .02; deep/mixed, OR = 0.24...
The Evaluation of Shear Wave Elastography Ultrasound in the Early Detection and Diagnosis of Vascular Disease محمد جايز السعدي

It is estimated that cardiovascular diseases (CVDs) are responsible for over 17.3 million deaths per year and are the leading causes of death and disability in the world. In one hand, atherosclerotic disease of the carotid arteries has been associated with the development of cerebrovascular events due to rupture of carotid plaques. Determining plaque vulnerability is critical when selecting the most suitable treatment for patients with carotid stenosis. On the other hand, venous thrombus diagnosis and ageing is critically important in allowing physicians to introduce an appropriate treatment plan. The decision whether or not to perform a thrombectomy or thrombolysis is dependent upon the age of the blood clot. Currently, clinical non-invasive ultrasound-based methods for plaque characterization are limited to visual assessment of plaque morphology and thrombus ageing and new quantitative methods are needed.

The aim of this research is to evaluate the utility of Shear Wave Elastography Ultrasound (SWEU) in characterising and ageing the status of atherothromboembolism disease. The current gold standard method to provide more detail about atherothromboembolism status is histopathology. Other modalities such as Magnetic Resonance Imaging (MRI), Computed Tomography Angiography (CTA) are available for diagnosis. MRI is considered the superior imaging modality regarding the atherothromboembolism status, but it has some limitations. SWEU is a novel imaging modality. SWEU is currently used to characterize and stage liver fibrosis and provide more details about the type of breast tumours; it is...

Comparison of Extracorporeal Shock Waves Therapy Versus Intermittent Pneumatic Compression Therapy in Breast Cancer-related Lymphedema. نرمين محمد عبدالحليم

Lymphedema is a chronic cumulative problem re­sulting from insufficiency or destruction of the lymphatic system. It is marked by unusual  accumulations of tissue proteins, edema, chronic inflammation, and fibrosis.  There are two types of LE ;Primary LE results from congenital anomaly of lymphatic vessels[5], while secondary LE is caused by many factors related to lymphatic stasis, as tumor lymph node infiltra­tion, lymph node dissection, radiotherapy, trauma, and infection.

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Long Term Effects of Low-Frequency Magnetic Field Therapy in Treatment Patients with Low Back Pain. نرمين محمد عبدالحليم
Low back pain influences majority of the population, especially in working-age in modernity. It interferes with activity of daily living. A low frequency magnetic field therapy field has been advantageous in patients suffering from low back pain. ...
Effect of Aerobic Exercise on Constipation in Employees in Al-Kharj, Saudi Arabia. نرمين محمد عبدالحليم
Chronic constipation is a prevalent disorderthat significantly reduces the quality of life particularly in sedentary subjects. The role of exercise in the management of chronic constipation is controversial. ...
Interaction of living cells with electric pulses: parameters and possible applications عمرو عادل عبد الغني
Remarkable improvements have been seen recently towards the applications of pulsed electric fields in permeabilizing the cell membranes. Under the normal functional activities of a living cell, the transmembrane potential is about -30 to -90 millivolts. External electric fields can induce on a living cell an extra component of transmembrane voltage. The magnitude of the added component is proportional to the strength of the external field. Both the resting and the induced component are superimposed during the incidence of the external field. The induced component will be dependent on the position, shape, and orientation of the cells with respect to the electric field. In suspensions, it also depends on the volume fraction occupied by the cells. The latent period between exposure and induction is in the order of microseconds but it can last longer if cells are in low conductivity medium. It should be also mentioned that as a consequence of this latent period, pulsed electric fields with frequencies more than 1 MHz or pulse durations shorter than 1 μs the induced transmembrane potential is inversely proportional to the frequency of the applied field and directly proportional to the pulse duration. In gigahertz range, or pulses in nanosecond range, induced voltage inside the cell become comparable or even greater than that induced on the plasma membrane. Low intensity and long duration electric pulses increase the electrophoretic lateral mobility of charged molecules in the membrane. In this review, principles and some applications of pulsed electric fields with their biological end ...
ELECTROPERMEABILIZATION USING NANOSECOND ELECTRIC PULSES: CONTROL BY PULSE NUMBERS عمرو عادل عبد الغني
The disruption of plasma membranes by in situ micro- and millisecond electric pulses has been observed for several decades. Exposures to nanosecond pulsed electric fields (nsPEF) are known to induce intracellular responses, such as apoptosis and poration of intracellular membranes. However, only few studies have been focused on its efficacy in electropermeabilization of the plasma membranes. The present work is a novel approach for electropermeabilization by increasing the internalization of impermeable molecules like Bleomycin (BLM) into Chinese hamster DC-3F lung fibroblasts using high intensity (40 kV/cm), and ultra-short (10 ns) electric pulses. The study revealed that cell membrane electropermeabilization using the previous electrical conditions depends on the number of pulses applied to cells suspended in low conductive medium (1 mS/cm) without significant loss of their viability using pulse numbers lower than 10000 np, total exposure time 100 sec and variable repetition frequency (10-100 Hz). The electropermeabilization efficiency was measured using cloning efficacy test. The results demonstrated an increase in the electropermeabilization efficiency by ~30% depending on BLM concentration and the number of pulses in the range (1000-10000 np). ...
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