بحوث أعضاء هيئة التدريس

أنت هنا

The Evaluation of Shear Wave Elastography Ultrasound in the Early Detection and Diagnosis of Vascular Disease محمد جايز السعدي

It is estimated that cardiovascular diseases (CVDs) are responsible for over 17.3 million deaths per year and are the leading causes of death and disability in the world. In one hand, atherosclerotic disease of the carotid arteries has been associated with the development of cerebrovascular events due to rupture of carotid plaques. Determining plaque vulnerability is critical when selecting the most suitable treatment for patients with carotid stenosis. On the other hand, venous thrombus diagnosis and ageing is critically important in allowing physicians to introduce an appropriate treatment plan. The decision whether or not to perform a thrombectomy or thrombolysis is dependent upon the age of the blood clot. Currently, clinical non-invasive ultrasound-based methods for plaque characterization are limited to visual assessment of plaque morphology and thrombus ageing and new quantitative methods are needed.

The aim of this research is to evaluate the utility of Shear Wave Elastography Ultrasound (SWEU) in characterising and ageing the status of atherothromboembolism disease. The current gold standard method to provide more detail about atherothromboembolism status is histopathology. Other modalities such as Magnetic Resonance Imaging (MRI), Computed Tomography Angiography (CTA) are available for diagnosis. MRI is considered the superior imaging modality regarding the atherothromboembolism status, but it has some limitations. SWEU is a novel imaging modality. SWEU is currently used to characterize and stage liver fibrosis and provide more details about the type of breast tumours; it is...

Comparison of Extracorporeal Shock Waves Therapy Versus Intermittent Pneumatic Compression Therapy in Breast Cancer-related Lymphedema. نرمين محمد عبدالحليم

Lymphedema is a chronic cumulative problem re­sulting from insufficiency or destruction of the lymphatic system. It is marked by unusual  accumulations of tissue proteins, edema, chronic inflammation, and fibrosis.  There are two types of LE ;Primary LE results from congenital anomaly of lymphatic vessels[5], while secondary LE is caused by many factors related to lymphatic stasis, as tumor lymph node infiltra­tion, lymph node dissection, radiotherapy, trauma, and infection.

...
Long Term Effects of Low-Frequency Magnetic Field Therapy in Treatment Patients with Low Back Pain. نرمين محمد عبدالحليم
Low back pain influences majority of the population, especially in working-age in modernity. It interferes with activity of daily living. A low frequency magnetic field therapy field has been advantageous in patients suffering from low back pain. ...
Effect of Aerobic Exercise on Constipation in Employees in Al-Kharj, Saudi Arabia. نرمين محمد عبدالحليم
Chronic constipation is a prevalent disorderthat significantly reduces the quality of life particularly in sedentary subjects. The role of exercise in the management of chronic constipation is controversial. ...
Interaction of living cells with electric pulses: parameters and possible applications عمرو عادل عبد الغني
Remarkable improvements have been seen recently towards the applications of pulsed electric fields in permeabilizing the cell membranes. Under the normal functional activities of a living cell, the transmembrane potential is about -30 to -90 millivolts. External electric fields can induce on a living cell an extra component of transmembrane voltage. The magnitude of the added component is proportional to the strength of the external field. Both the resting and the induced component are superimposed during the incidence of the external field. The induced component will be dependent on the position, shape, and orientation of the cells with respect to the electric field. In suspensions, it also depends on the volume fraction occupied by the cells. The latent period between exposure and induction is in the order of microseconds but it can last longer if cells are in low conductivity medium. It should be also mentioned that as a consequence of this latent period, pulsed electric fields with frequencies more than 1 MHz or pulse durations shorter than 1 μs the induced transmembrane potential is inversely proportional to the frequency of the applied field and directly proportional to the pulse duration. In gigahertz range, or pulses in nanosecond range, induced voltage inside the cell become comparable or even greater than that induced on the plasma membrane. Low intensity and long duration electric pulses increase the electrophoretic lateral mobility of charged molecules in the membrane. In this review, principles and some applications of pulsed electric fields with their biological end ...
ELECTROPERMEABILIZATION USING NANOSECOND ELECTRIC PULSES: CONTROL BY PULSE NUMBERS عمرو عادل عبد الغني
The disruption of plasma membranes by in situ micro- and millisecond electric pulses has been observed for several decades. Exposures to nanosecond pulsed electric fields (nsPEF) are known to induce intracellular responses, such as apoptosis and poration of intracellular membranes. However, only few studies have been focused on its efficacy in electropermeabilization of the plasma membranes. The present work is a novel approach for electropermeabilization by increasing the internalization of impermeable molecules like Bleomycin (BLM) into Chinese hamster DC-3F lung fibroblasts using high intensity (40 kV/cm), and ultra-short (10 ns) electric pulses. The study revealed that cell membrane electropermeabilization using the previous electrical conditions depends on the number of pulses applied to cells suspended in low conductive medium (1 mS/cm) without significant loss of their viability using pulse numbers lower than 10000 np, total exposure time 100 sec and variable repetition frequency (10-100 Hz). The electropermeabilization efficiency was measured using cloning efficacy test. The results demonstrated an increase in the electropermeabilization efficiency by ~30% depending on BLM concentration and the number of pulses in the range (1000-10000 np). ...
A rehabilitation program recommendation for children with juvenile psoriatic arthritis. نرمين محمد عبدالحليم
Juvenile psoriatic arthritis has become a well recognized subtype within the inflammatory arthritis of childhood. Fewer trials describing the outcomes of different rehabilitation regimens were identified. ...
Terbinafine Hydrochloride 1% Iontophoresis for the Treatment of Toenail Onychomycosis: A Randomized Placebo Controlled Study. نرمين محمد عبدالحليم
Successful topical treatment with deep penetration of toenail Onychomycosis remains hard as the delivery of effective degrees of antifungal drug to the site of action is very difficult. ...
Extracorporeal Shock Wave Therapy in the Treatment of Cellulite: A Prospective Randomized Controlled Trial نرمين محمد عبدالحليم
The aim of the study was to demonstrate the efficacy and safety of extracorporeal shock wave therapy in cellulite treatment ...
Capsaicin phonophoresis versus transcutaneous electrical nerve stimulation in the treatment of pruritus in lichen simplex chronicus: a prospective randomized controlled study. نرمين محمد عبدالحليم

Lichen Simplex Chronicus is characterized by circumscribed, lichenified, prutitic patches that may develop on the neck, upper thigh, lower legs, ankles, extensor surface of forearms, back, scalp, vulva, pubis, and scrotum.

...
QR Code for https://cams.psau.edu.sa/ar/sources/research