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Staphylococci, Catecholamine Inotropes and Hospital-Acquired Infections نورا حمد الضعيان

The development of the field of microbial endocrinology has now spanned 23 years from the time I first proposed its creation in 1992 (Lyte 1992; Lyte and Ernst 1992). During that time, this interdisciplinary field has experienced two of the characteris- tics of a typical microbial growth curve: a long lag phase during which acceptance of articles was problematic to say the least, followed by an early log phase of growth characterized by increasing awareness that the intersection of microbiology, endo- crinology and neurophysiology offers a unique way to understand the mechanisms underlying health and disease. This book, I am happy to report, comes at the start of that early log phase with the possibilities for future rapid growth. 

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Evaluation of Total Oxidative Stress, Total Antioxidant Capacity Along with Selenium and Vitamin E Level among Saudi Women Experiencing Unexplained Recurrent Miscarriage and Intrauterine Foetal Death نورا حمد الضعيان

Introduction: Oxidative stress is integrated with declined female fertility. Our modern sedentary life style and exposure to toxins make vulnerable to body to increased amount of oxidative stress and lead to higher oxidative damage to DNA and may affect ova, sperm or the development of the embryo, leading to infertility, miscarriage and congenital defects. In the present study our aim was to assess the concentration of total oxidative stress, total antioxidant capacity, selenium and vitamin E level in women suffering from recurrent spontaneous miscarriage and intra uterine foetal death and compare levels with normal pregnant women. 

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Early detection of breast cancer using DC bio-impedance technique سفيان محمد الحبيب منصوري

Breast cancer is the leading cause of death among women around the world. Studies confirm that early-stage cancer detection can lead to better healing. This research project aims to offer a system for early detection of women breast cancer based on the technique of DC electric bio-impedance

Mammography remains the essential technique for breast exploration, the most successful in terms of monitoring and early detection of breast cancer. Unfortunately, it is an invasive, expensive method and women do not go directly for screening. Thus, we propose in this research project to design a smart mammograph for early diagnosis of breast cancer using electrical bio-impedance

Electrical bio-impedance has a high diagnostic potential for various diseases. Indeed, an impedance value different from the normal can inform us about a physiological abnormality of the individual

Indeed, this research project offers a non-invasive system that allows to simultaneously measuring the impedances of the two breasts of a patient, to compare the result and if there is a significant difference, it means that there is a problem in one of the breasts. Once the system finalized, we will carry out an impedance measurement campaign of healthy women and women with cancer to establish a meaningful database and offer a real-time automatic screening system

This research project is only the first phase. The second phase will focus on increasing the number of electrodes to precisely locate the tumor, create an image and transmit it to a smartphone

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Muscle shear wave elastography in idiopathic inflammatory myopathies: a case–control study with MRI correlation عبدالرحمن محمد الفريح
Objective To investigate muscle stiffness in patients with idiopathic inflammatory myopathies (IIM) using shear wave elastography (SWE) and to correlate the results with muscle strength and MRI features of myositis. Materials and methods Muscle shear wave velocity (SWV) was measured in 23 active IIM patients (13 females, mean age 50.4 ± 16.1 years) and 23 matched healthy controls (13 females, mean age 50.7 ± 16.2 years). The investigated muscles included the vastus lateralis (VL), rectus femoris (RF), vastus medialis (VM) vastus intermedius (VI), biceps femoris (BF), semitendinosus (ST), semimembranosus (SM) and the biceps brachii (BB) scanned during relaxed resting and passive stretching positions. Participants performed multiple tests to evaluate their muscle strength. IIM patients had a thigh MRI to assess degrees of oedema, fatty infiltration and atrophy. Results In the resting position, IIM patients had a 12.9–22.2% significantly lower SWV (p < 0 xss=removed xss=removed xss=removed xss=removed xss=removed xss=removed xss=removed xss=removed xss=removed> Conclusion Shear wave elastography may detect abnormal reduced thigh stiffness in IIM patients. SWE measurements were significantly associated with muscle weakness and MRI signs of oedema and atrophy. Future research should investigate this new technology for monitoring disease activity. ...
The effect of ageing on shear wave elastography muscle stiffness in adults عبدالرحمن محمد الفريح
Background Skeletal muscle undergoes structural changes with ageing which may alter its biomechanical properties. Shear wave elastography (SWE) may detect these changes by measuring muscle stiffness. Aims To investigate muscle stiffness in healthy young, middle-aged and elderly cohorts using SWE and correlate it with muscle strength and mass. Methods Shear wave velocity (SWV) was measured in the quadriceps, hamstrings and biceps brachii of 26 young (range 20–35 years), 21 middle-aged (40–55) and 30 elderly (77–94) volunteers. The participants performed several muscle tests to evaluate their strength. The One-way ANOVA was used to test the muscle stiffness differences between the groups and the Pearson’s correlation coefficient to evaluate the relationship between SWV and muscle strength. Results The overall resting muscle SWV gradually decreased with age but was only significantly reduced in the elderly group (p < 0 xss=removed xss=removed xss=removed xss=removed xss=removed> Conclusions Ageing was associated with a decline in skeletal muscle stiffness which positively correlates with muscle weakness. Further research is needed to evaluate the promising role of SWE as a biomarker for sarcopenia assessment and potential falls risk prediction in elderly individuals. ...
Shear-Wave Elastography of Benign versus Malignant Musculoskeletal Soft-Tissue Masses: Comparison with Conventional US and MRI عبدالرحمن محمد الفريح
Purpose To examine if shear-wave elastography (SWE) improves the accuracy of diagnosing soft-tissue masses as benign or malignant compared with US alone or in combination with MRI. Materials and Methods Two hundred six consecutive adult participants (mean age, 57.7 years; range, 18–91 years), including 89 men (median age, 56.0 years; range, 21–91 years) and 117 women (median age, 59.1 years; range, 18–88 years), who were referred for biopsy of a soft-tissue mass were prospectively recruited from December 2015 through March 2017. Participants underwent B-mode US, MRI, and SWE prior to biopsy. Three musculoskeletal radiologists independently reviewed US images alone, followed by US and MRI images together, and classified lesions as benign, probably benign, probably malignant, or malignant. For SWE, the area under the receiver operating characteristic (ROC) curve (AUC) was calculated for transverse shear-wave velocity (SWV). Multivariable logistic regression was used to investigate the association between SWE and malignancy alongside individual demographic and imaging variables. Results At histologic examination, 79 of 206 (38%) participants had malignant lesions. SWV showed good diagnostic accuracy for lesions classified as benign or probably benign by US alone (AUC = 0.87 [95% confidence interval {CI}: 0.79, 0.95]). SWV did not provide substantive diagnostic information for lesions classified as probably malignant or malignant, whether the classification was made with or without MRI. However, multivariable modeling indicated that diagnostic accuracy may vary by lesion position (interaction P = .02; superficial, odds ratio [OR] = 17.7 [95% CI: 1.50, 207], P = .02; deep/mixed, OR = 0.24...
The Evaluation of Shear Wave Elastography Ultrasound in the Early Detection and Diagnosis of Vascular Disease محمد جايز السعدي

It is estimated that cardiovascular diseases (CVDs) are responsible for over 17.3 million deaths per year and are the leading causes of death and disability in the world. In one hand, atherosclerotic disease of the carotid arteries has been associated with the development of cerebrovascular events due to rupture of carotid plaques. Determining plaque vulnerability is critical when selecting the most suitable treatment for patients with carotid stenosis. On the other hand, venous thrombus diagnosis and ageing is critically important in allowing physicians to introduce an appropriate treatment plan. The decision whether or not to perform a thrombectomy or thrombolysis is dependent upon the age of the blood clot. Currently, clinical non-invasive ultrasound-based methods for plaque characterization are limited to visual assessment of plaque morphology and thrombus ageing and new quantitative methods are needed.

The aim of this research is to evaluate the utility of Shear Wave Elastography Ultrasound (SWEU) in characterising and ageing the status of atherothromboembolism disease. The current gold standard method to provide more detail about atherothromboembolism status is histopathology. Other modalities such as Magnetic Resonance Imaging (MRI), Computed Tomography Angiography (CTA) are available for diagnosis. MRI is considered the superior imaging modality regarding the atherothromboembolism status, but it has some limitations. SWEU is a novel imaging modality. SWEU is currently used to characterize and stage liver fibrosis and provide more details about the type of breast tumours; it is...

Comparison of Extracorporeal Shock Waves Therapy Versus Intermittent Pneumatic Compression Therapy in Breast Cancer-related Lymphedema. نرمين محمد عبدالحليم

Lymphedema is a chronic cumulative problem re­sulting from insufficiency or destruction of the lymphatic system. It is marked by unusual  accumulations of tissue proteins, edema, chronic inflammation, and fibrosis.  There are two types of LE ;Primary LE results from congenital anomaly of lymphatic vessels[5], while secondary LE is caused by many factors related to lymphatic stasis, as tumor lymph node infiltra­tion, lymph node dissection, radiotherapy, trauma, and infection.

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Long Term Effects of Low-Frequency Magnetic Field Therapy in Treatment Patients with Low Back Pain. نرمين محمد عبدالحليم
Low back pain influences majority of the population, especially in working-age in modernity. It interferes with activity of daily living. A low frequency magnetic field therapy field has been advantageous in patients suffering from low back pain. ...
Effect of Aerobic Exercise on Constipation in Employees in Al-Kharj, Saudi Arabia. نرمين محمد عبدالحليم
Chronic constipation is a prevalent disorderthat significantly reduces the quality of life particularly in sedentary subjects. The role of exercise in the management of chronic constipation is controversial. ...
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